Schizophrenia by Philip G. Janicak Stephen R. Marder Rajiv Tandon & Morris Goldman

Author:Philip G. Janicak, Stephen R. Marder, Rajiv Tandon & Morris Goldman
Language: eng
Format: epub
Publisher: Springer New York, New York, NY

Cytochrome P450 1A2

Cytochrome P450 1A2 (CYP1A2) is an isoenzyme responsible for the metabolism of a number of drugs (e.g., clozapine is metabolized to norclozapine by CYP1A2). Genetic variations which produce PMs or UMs appear to be very rare [21]. Cigarette smoking induces the expression of CYP1A2, leading to a more rapid clearance of drugs metabolized by this isoenzyme [21]. Since a large number of psychotic patients smoke, it is important to consider this when prescribing a CYP1A2-metabolized drug as lower-than-expected blood concentrations may result, especially if there is also a genetic propensity for rapid CYP1A2 metabolism.

Clozapine, olanzapine, and promazine are commonly used antipsychotics metabolized by the CYP1A2 isozyme.

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